TARDBP and frontotemporal dementia: The same has been noted for fibrils of α-synuclein, wild-type or mutants, in synucleinopathies (Li et al., 2018a; Li et al., 2018b; Guerrero-Ferreira et al., 2018; Guerrero-Ferreira et al., 2020; Schweighauser et al., 2020) or TDP-43 in ALS/FTD (amyotrophic lateral sclerosis/frontotemporal dementia) (Arseni et al., 2021) and synthetic filaments.