The site-specific acetylation of K280 reproduces with increased outcome the effect of K280Q acetylation mimicking mutant on tau aggregation by forming rather oligomers and short fibrils instead of the long filaments observed for unmodified tau consistently with the increased seeding efficiency and toxicity of this mutant in AD models of tau pathology (Min et al., 2010; Cohen et al., 2011; Gorsky et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.