MAPT and tauopathy: Very recently, cryo-EM, remarkably exploited by Goedert, Scheres and collaborators, provides structural details at near-atomic resolution on amyloid folds of tau protein either from patients with various tauopathies or made in vitro with heparin as aggregation inducer (Fitzpatrick et al., 2017; Falcon et al., 2018a; Falcon et al., 2018b; Zhang et al., 2019a; Falcon et al., 2019; Zhang et al., 2020) highlighting profound structural discrepancies.