Hyperphosphorylation, a common feature of tau proteins in NFTs and inclusions from diverse tauopathies, is mainly found within the N- and C-terminal regions flanking the amyloid core (Morishima-Kawashima et al., 1995a; Hanger et al., 1998; Alonso et al., 2001; Hanger et al., 2007; Hanger et al., 2009; Šimić et al., 2016) that greatly inhibit the formation of filaments (Abraha et al., 2000; Lövestam et al., 2021). This evidence concerns the gene MAPT and tauopathy.