VEGFR inhibitors have been found to moderate angiogenesis and lymphangiogenesis in the inflamed middle ear mucosa and improve OM (Cheeseman et al., 2011). Our previous study showed that micro-particles increased VEGFA expression in human middle epithelial cells, as increased VEGFA was detected in transcriptome analysis and validated by quantitative real-time polymerase chain reaction (qRT-PCR) (Song et al., 2013). Here, VEGFA is linked to ocular melanoma.