Indeed, the combination of HDAC3 inhibitor RGFP966 with a DNA demethylation reagent, 5-aza-2-deoxycytidine, synergistically enhanced the expression of several tumor suppressors such as p16, PTEN, STAT1, CD40, and large non-coding RNA MEG3, accompanied by growth suppression. This evidence concerns the gene CD40 and neoplasm.