While comparing the 2D and 3D culture models as drug-testing platforms in breast cancer, Imamura et al. (2015) (18) reported that the 3D model with the breast cancer cell line BT-474 had a lower level of caspase-3 than the 2D model, suggesting the anti-apoptotic nature of dense multi-cellular spheroid model of BT-474 cell line. Here, CASP3 is linked to breast carcinoma.