KEGG analysis revealed that compared to C2, C1 showed the activation of signaling pathways for liver metabolism, including bile secretion, cholesterol metabolism, glycolysis/gluconeogenesis, and chemical carcinogenesis (DNA adducts and receptor activation), while a suppression of cancer-associated signaling pathways such as bladder cancer, the cell cycle, central carbon metabolism in cancer, and PI3K-Akt signaling pathway (Figure 3C). Here, AKT1 is linked to urinary bladder cancer.