uncovered that the mesencephalic astrocyte-derived neurotrophic factor inhibited epithelial–mesenchymal transition and liver cancer progression via the suppression of the nuclear factor kappa-light-chain-enhancer of activated B cells/Snail signaling, cultivating a nexus among endoplasmic reticulum stress, and liver cancer inflammation and progression (5). This evidence concerns the gene SNAI1 and liver cancer.