GRIN2D and cancer: On the other hand, the high GRIN2D expression group had an upregulation of pathways like proteoglycans in cancer, the PI3K-Akt signaling pathway, cell adhesion molecules, and activation of processes like the positive regulation of cell activation, regulation of leukocyte proliferation, downregulation of bile secretion, cholesterol metabolism, and suppression of processes like the alcohol metabolic process and lipid homeostasis (Figures S6C, D).