The massive production of cholesterol thereby facilitates the expression of several tumor related signaling proteins, such as CD24 (promoting angiogenesis) (43), TGFβ (promoting epithelial-mesenchymal transition) (44), matrix metallopeptidase (promoting migration) (45), and CD44 (promoting adhesion) (46), which need to anchor on a lipid raft. The gene discussed is TGFB1; the disease is neoplasm.