TP53 and neoplasm: In the first model (basal tumors), we noticed that in Wwox (w-KO), p53 (p-KO) and Wwox and p53(D-KO) knockout mice there is a drastic reduction in the expression level of Tet1 in all tumors tested compared to normal mammary gland tissue isolated from either wild type mice (wt) or knockout mice (N-KO), without preferential expression of any of Tet1 exon (Figures 4A, B), indicating that all TET1 isoforms were downregulated, which might indicate that all TET1 isoforms can be deleted in specific tumor types.