In addition to Tregs, multiple immune cell infiltration and chemokines/chemokine receptors were found to be positively correlated with SOAT1 expression in glioma, such as macrophages, CCL16, and CCL20. In fact, increasing evidence shows that there is a strong connection between the tumor metabolic microenvironment and the immune microenvironment. The gene discussed is SOAT1; the disease is central nervous system cancer.