The unsaturated fatty acid 20-hydroxyeicosatetraenoic acid, a catalytic product of cytochrome P450 4A (CYP4A), along with VEGF and TGF-β, promoted angiogenesis by enhancing the migration of glioma-associated macrophages (GAMs), and inhibition of CYP4A prolonged survival and normalized tumor vasculature in glioma (49). This evidence concerns the gene VEGFA and central nervous system cancer.