A total of 12 B-ALL xenograft models were developed by injecting EV or LV-Nrf2 transfected RS4:11 cells into NOD/SCID mice, as described, to functionally correlate Nrf2 overexpression with the response to tumor cells proliferating, growth and VCR sensitisation (Figures 5A, B). The gene discussed is NFE2L2; the disease is acute lymphoblastic leukemia.