Interestingly, the upregulated genes, according to the KEGG 2021 Human assignment, also hold functions in several immune-mediated diseases like rheumatoid arthritis (CXCL6, IL6, CXCL8, IL23A, CCL2, CXCL1, CXCL3, CXCL2, TNF, CXCL5) as well as parasitic infections like amoebiasis (IL6, CXCL8, CXCL1, PRDX1, FN1, TNF and other). The gene discussed is CXCL8; the disease is rheumatoid arthritis.