Interestingly, the upregulated genes, according to the KEGG 2021 Human assignment, also hold functions in several immune-mediated diseases like rheumatoid arthritis (CXCL6, IL6, CXCL8, IL23A, CCL2, CXCL1, CXCL3, CXCL2, TNF, CXCL5) as well as parasitic infections like amoebiasis (IL6, CXCL8, CXCL1, PRDX1, FN1, TNF and other). This evidence concerns the gene CCL2 and rheumatoid arthritis.