HIF1A and renal cell carcinoma: We therefore additionally analyzed the pathways, which were similarly or equally expressed in tumor tissue and cell cultures: Interestingly, the analysis revealed an equal expression of genes crucial in the development and progression of renal cancer, such as HIF1A and VEGFA. RCC, especially the clear cell subtype, highly relies on aerobic glycolysis despite the presence of oxygen, and therefore promotes a pseudo-hypoxic gene expression: This circumstance is known as the Warburg-effect and has been investigated over decades (40).