While the Glyoxylate and dicarboxylate metabolism pathway which C2 enriched in, acyl-CoA synthetase short chain family member 2(ACSS2) was involved in the activation of Acetyl coenzyme A and the fatty acid degradation pathway can indirectly promote the process and researchers have found that ACSS2 activates the CoA under metabolic stress to encourage the tumor cells to use acetic acid as an additional nutrient source that allows the tumor cells to adapt to the harsh metabolic environment and keep the tumor cells alive (29). This evidence concerns the gene ACSS2 and neoplasm.