Our results, which showed that the FAM222A-AS1/miR-let-7f/MYH9 axis promotes CRC cell proliferation and invasion, provided the first evidence that the tumor metastasis-associated gene MYH9 is a target of miR-let-7f in CRC, and that FAM222A-AS1 may be a novel prognosis-associated lncRNA and therapeutic candidate for CRC. The gene discussed is FAM222A; the disease is neoplasm.