CD274 and non-small cell lung carcinoma: Since the combination therapy minimizes the toxic effects on normal cells and induces cytotoxic effects on the cancer cells, it also allows the possibility to further combine more than one inhibitor, especially when considering the mutation/genomic landscape, as shown in a recent clinical trial that combined durvalumab (human IgG1κ monoclonal antibody that blocks PD-L1 binding to PD-1 & CD80) and gefitinib (EGFR tyrosine kinase inhibitor) to treat TKI-naïve patients with EGFR mutation-positive NSCLC (6).