Additionally, we also constructed a risk score system based on LSM5, LSM10, LSM12, and lsm14B, which was also identified as an independent prognostic factor with optimal predictive ability with reliable C-indexes [0.676 (95% CI, 0.621–0.731) in the TCGA HCC cohort and 0.658 (95% CI, 0.571–0.744) in the ICGC HCC cohort]. This evidence concerns the gene LSM14B and hepatocellular carcinoma.