EP300 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, we had earlier found that CLF also suppresses STAT expression in CML and consequently downregulated stem cell maintenance factors like hypoxia-inducible factor-1α and -2α and Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) (10).