SPARC has a higher expression among lower grade (Supplementary Figure 3A), Cluster 2 (Supplementary Figure 3B), low-risk group (Supplementary Figure 3C), IHD status of mutant (Supplementary Figure 3D), GBM subtype of mesenchymal (Supplementary Figure 3E), and IDH status of mutant in LGG (Supplementary Figure 3E) groups. The gene discussed is IDH1; the disease is glioblastoma.