Tanshinone monomers could inhibit the proliferation of human colorectal cancer and gastric cancer cells, induce cell cycle arrest, and promote cell apoptosis, which was related to downregulating the expression level of HIF-1 (hypoxia inducible factor-1), VEGFR, bFGF (68), inhibiting tumor angiogenesis, suppressing the expression level of transcription related protein, down-regulating anti-apoptotic protein Bcl-2, while upregulate the pro-apoptotic proteins p53, Bax, cleaved caspase-3, and p21. Here, TP53 is linked to colorectal cancer.