Artemisinin and Dihydroartemisinin exhibited favorable anti-tumor activity in inhibiting proliferation, migration, and invasion of tumor cells, which was attributed to up-regulating the expression of RECK (reversion inducing cysteine rich protein with Lazal motif) and down-regulating the expression of MMP-2 and N-Cadherin (39). This evidence concerns the gene SPARC and neoplasm.