BCL2 and hepatocellular carcinoma: The combination of Hydroxycamptothecin (0.625 μmol/L) and Celecoxib (30 mg/L) could promote cell apoptosis of human hepatoma cell line SMMC-7721 by down-regulating the expression of Bcl-2 and COX-2, up-regulating the expression of Bax (17).