TP53 and cancer: Harringtonine (13), Vincristine (21, 22), Matrine and Oxymatrine (32) and Lycium barbarum polysaccharide (84–86), could downregulate the phosphorylation of PI3K, Akt and mTOR in PI3K/Akt/mTOR signaling pathway and the protein expression in Notch pathway, inhibit the binding to Estrogen receptor β, upregulate p53, p21, and downregulate CDK2, cyclinA, cyclinB1, cyclinD1, cyclinE, Cdc2, Cdc25C, thus leading to cell cycle arrest and inhibit cancer cell growth.