Natural products such as As2O3 (53–56) and Triptolide (49) could upregulate tumor suppressor genes PTEN, p53 (54), APC (55), FOXO1 (56), and miR-145, and downregulate MMP2 and MMP9 to inhibit tumor angiogenesis, migration, and invasion. The gene discussed is FOXO1; the disease is neoplasm.