AKT1 and cancer: Homoharringtonine, Camptothecin, Vincristine, Artemisinin, Dihydroartemisinin and Tanshinone could downregulate Ras-MAPK, PI3k-Akt, Wnt-β-catenin, STAT3 (72), ATAD2, and Notch1, while upregulate of P53, P21, IGFBP3, NDRG1 to activate mitochondrial mediated endogenous apoptotic caspase pathway, therefore, downregulate the level of anti-apoptotic gene Bcl-2, Bcl-xL, survivin, livin (48, 76), as well as upregulate the pro-apoptotic gene Bax, cleaved caspase-3, 8, 9, AIF, and cleaved PARP1 to promote cancer cell apoptosis (33).