Artemisinin inhibited the proliferation and promote apoptosis of hepatocellular carcinoma cell lines Huh7 and SMMC-7721 by inhibiting the phosphorylation of Akt and S6 in mTOR signaling pathway of Huh7 cells and the phosphorylation of C-myc and S6 in mTOR signaling pathway of SMMC-7721 cells (40). The gene discussed is MTOR; the disease is hepatocellular carcinoma.