Genistein could reverse drug resistance of 5-fluorouracil-resistant hepatoma cell line Bel-7402/5Fu by up-regulating the expression of Akt and mTOR in PI3K/Akt/mTOR pathway, down-regulating the expression autophagy-related genes of Beclin and LC3 to promote cell autophagy (61). Here, AKT1 is linked to hepatocellular carcinoma.