Ginsenosides (81–83), Tanshinones (68) and Lentinan (95) could inhibit Akt phosphorylation and the corresponding PI3K/Akt/mTOR pathway, inhibit phosphorylation of IκBα, NF-κB-p65, upregulate the expression of SHP-1, downregulate the protein level of angiogenesis-associated HIF-1α, MMP-2, MMP-9, VEGF, bFGF and Cyc-D1 to inhibit angiogenesis and the proliferation of tumor cells. This evidence concerns the gene HIF1A and neoplasm.