Emodin inhibited the proliferation, migration, and invasion, suppressed the cellular glycolysis and promoted apoptosis of endometrial cancer cell line HEC-1-B and gastric cancer cell lines BGC-823 and AGS, inhibited the xenograft growth of human colon cell line CT26 in nude mice model, which was attributed to downregulating the expression of CD44 and carbonic anhydrase IX protein (74), peroxidase Prx V, increasing intracellular ROS (75), downregulating anti-apoptosis proteins Bcl-2 and Pro-caspase 3, upregulating pro-apoptosis proteins Caspase3, Bax and HIF-α (76). This evidence concerns the gene BCL2 and gastric cancer.