In summary, this study identified a LINC01929/miR-6875-5p/ADAMTS12 regulatory axis highly associated with advanced bladder cancer development through a network of core lncRNAs-miRNAs-mRNAs and validation of clinical samples, and elucidated that LINC01929 upregulates miR-6875-5p via sponge adsorption and upregulates the pro-cancer molecule ADAMST12, which in turn promotes the progression, invasion, and metastasis of advanced bladder cancer. This evidence concerns the gene ADAMTS12 and urinary bladder cancer.