TKIs also can improve the sensitivity of radiotherapy from other aspects: to enhance radiation-induced apoptosis by inhibiting ras-mediated PI3K-AKT pathway; to inhibit the repair of DNA damage after radiotherapy; to reduce cell proliferation and accelerating re-proliferation by inhibiting EGFR pathway; to inhibit the formation of neovascularization and weaken tumor invasion and distant metastasis (20–22). This evidence concerns the gene EGFR and neoplasm.