CD4/CD8 subpopulation analyses revealed a heterogeneous CD4/CD8 distribution in both Nipako/ko and Nipawt/wt lymphomas (Figure 3E), which was, despite minor variations, similar in both groups with distinct CD4/CD8-double positive, CD4/CD8-double negative, and CD4- and CD8-single positive populations. The gene discussed is CD4; the disease is lymphoma.