Consequently, the expression of circulating miR-155, miR-410, and miR-181a/b and its putative gene-targets PDCD4, WNT5A, MET, and EGFR had a strong inverse relation in high-grade glioma, thereby suggesting that the potential roles of miR-155, miR-410, and miR-181a/b in oncogenesis of glioma tumors. The gene discussed is EGFR; the disease is central nervous system cancer.