Consequently, the expression of circulating miR-155, miR-410, and miR-181a/b and its putative gene-targets PDCD4, WNT5A, MET, and EGFR had a strong inverse relation in high-grade glioma, thereby suggesting that the potential roles of miR-155, miR-410, and miR-181a/b in oncogenesis of glioma tumors. This evidence concerns the gene PDCD4 and central nervous system cancer.