F8 and hemophilia A: Emicizumab, a bispecific monoclonal antibody that mimics the activity of FVIII by binding activated factors IX and X, maintains a level of hemostatic activity estimated at 9–10% of FVIII activity [11, 12] and thus offers the potential for a clinically meaningful reduction of bleeding episodes in patients with hemophilia A who have developed inhibitors compared to on-demand/prophylactic use of BPAs [4, 9, 10].