What is more, after adjusting for age and male in model 1 and age, male, smoke, hypertension, DM, hyperlipidemia, LDL-C, and Gensini score in model 2, AIM2 was still an independent predictor of MACEs in both adjusted models 1 (HR, 1.430; 95% CI, 1.173-1.745; p < 0.001) and 2 (HR, 1.453; 95% CI, 1.086-1.945; p = 0.012) (Table 5). The gene discussed is AIM2; the disease is hypertensive disorder.