PDYN and rheumatoid arthritis: Alonso et al. found enhanced release levels of preproopiomelanocortin and preprodynorphin in the hypothalamus of mice by acupuncture; preproopiomelanocortin and preprodynorphin have positive effects on anti-inflammatory pain and a strengthening analgesic effect in the human body [23], which also explained the excellent effect of acupuncture and moxibustion of TCM on relieving RA pain.