Wang et al. found that FOXO1 promoted the polarization of M0 to M2 and the recruitment of M2 macrophages in the tumor microenvironment through the transcriptional regulation of CCL20 and CSF-1 to promote tumor proliferation [11]; Mai et al. revealed that compared with normal tissues, the expression of IL-33 in ESCC tissue was significantly increased, and the infiltration of M2-like macrophages into ESCC tumor tissue was significantly enhanced. Here, FOXO1 is linked to esophageal squamous cell carcinoma.