As to determine the neighbor genes’ biological interaction network of these 20 stemness-related genes in HNSCC, tab Network in cBioPortal and the 50 most as often altered neighbor genes were displayed and the top 10 frequent alterations were PIK3CA, FGF3, FGF19, FGF4, DVL3, P3H2, GNB4, COL22A1, COL14A1, and PLOD2 (Figure 4B and Table 1). This evidence concerns the gene PLOD2 and head and neck squamous cell carcinoma.