In addition, the study also found that YAP1/SOX2 transcriptional stress triggers activation of reprogrammable HNSCC to obtain stems, while triple SOX2, CD44v9, and YAP1 may be useful for selecting high-risk CSCs with normal function (Omori et al., 2019). The gene discussed is YAP1; the disease is head and neck squamous cell carcinoma.