TXNRD1 and hepatocellular carcinoma: According to previous studies, inhibition of GLUT1 could impair the growth and migratory potential of HCC cells and reduce glucose uptake and lactate secretion, whereas inhibition of TXNRD1 hinders the proliferation of HCC cells and induces apoptosis in vitro (Amann et al., 2009; Lee et al., 2019).