In the Molecular Signature Database (MSigDB) “hallmark” collection of major biological categories, the upregulated genes in the high-risk group were mainly enriched in tumor-promoting and proliferation pathways, such as DNA repair, Myc targets, E2F targets, G2M checkpoint, mitotic spindle, and PI3K/AKT mTOR signaling pathway. The gene discussed is AKT1; the disease is neoplasm.