Among the actionable alterations, MET amplification exhibited the highest population frequency, while EGFR E746_A750delELREA, EGFR T790M, EML4-ALK (exon 20: exon 20) fusion, and KRAS G12C displayed a 100% consistency between the tumor tissue and pericardial effusions. This evidence concerns the gene EML4 and pericardial effusion.