Among them, IDH1, TP53, CDK4, EP300, EPHA3, MAP3K1, PRDM1, and RBM10 displayed a 100% coincidence rate of genetic alteration between pericardial effusion and paired tumor tissue, while KRAS, CDK8, DOT1L, and EGFR had a coincidence rate of 50% or more. This evidence concerns the gene DOT1L and neoplasm.