Figure 9A and Figure 9B demonstrated the panorama of immune cell infiltration in the tumor microenvironment of ESCC and the correlation of immune cell score, respectively. After integrating SPOCD1 gene expression and immune cell infiltration score, we comprehensively analyzed the infiltrating immune cells, which were significantly correlated with SPOCD1 expression. The results showed that SPOCD1 expression was positively correlated with Macrophages M0 and Mast cells activated cells, and negatively correlated with plasma cells and T cells follicular helper cell infiltration (Figure 9C). The gene discussed is SPOCD1; the disease is neoplasm.