It has been shown that the knockdown of FABP4 leads to increased 5-levels of hydroxymethylcytosine in DNA, downregulation of key genes associated with ovarian cancer metastasis, and reduced survival of replication to cancer cells (Furuhashi, Saitoh, Shimamoto, & Miura, 2014). The gene discussed is FABP4; the disease is ovarian carcinoma.