The inhibitor hippuristanol was used to highlight the role of eIF4A in the translation of two proteins which have a major contributory role in AD which have long structured 5′-UTRs such as in the microtubule associated protein Tau (MAPT) and amyloid β precursor protein (APP) genes encoding Tau and amyloid-beta peptide (Bottley et al., 2010). The gene discussed is APP; the disease is Alzheimer disease.