The eIF4A inhibitor hippuristanol significantly reduced RAN translation of CGG-repeat expansions in FMR1 in FXTAS (Kearse et al., 2016) and GGGGCC-repeat expansions in C9ORF72-ALS/FTD (Green et al., 2017). Here, C9orf72 is linked to fragile X-associated tremor/ataxia syndrome.