TBK1 and amyotrophic lateral sclerosis: Additionally, the RNA helicase DDX58 (Rig-1) has also been shown to be misregulated in TDP43-ALS (MacNair et al., 2016); while genome wide analysis has highlighted DHX58 and other components of the TBK1-related immune pathway as a risk factor for the form of FTLD-TDP (Pottier et al., 2019).