Interestingly, FTD exists on a disease spectrum with ALS and mutations in TBK1 have been identified as causative of both ALS and FTD (Cirulli et al., 2015; Freischmidt et al., 2015; Pottier et al., 2015) highlighting the potential role of DHX58 in these diseases. Here, TBK1 is linked to frontotemporal dementia.