The eIF4A inhibitor hippuristanol significantly reduced RAN translation of CGG-repeat expansions in FMR1 in FXTAS (Kearse et al., 2016) and GGGGCC-repeat expansions in C9ORF72-ALS/FTD (Green et al., 2017). Here, EIF4A1 is linked to amyotrophic lateral sclerosis.