Of particular interest, the partial depletion of Drosophila eIF4B and eIF4H1, two translation initiation co-factors stimulating the activity of eIF4A, lead to varying degrees of suppression of the rough eye phenotype in in vivo in both FXTAS and C9ORF72-ALS/FTD flies (Goodman et al., 2019; Linsalata et al., 2019) while depletion of the RNA helicase DDX3X leads to a strong inhibition of the neurodegenerative phenotype in FXTAS (Linsalata et al., 2019). Here, EIF4A1 is linked to fragile X-associated tremor/ataxia syndrome.