Multiple studies identified the requirement of the general translation initiation factors eIF4A, eIF4B and eIF4H in the RAN translation of CGG- and GGGGCC-repeat transcripts in FXTAS and C9ORF72-ALS/FTD respectively (Kearse et al., 2016; Green et al., 2017; Tabet et al., 2018; Goodman et al., 2019; Linsalata et al., 2019). This evidence concerns the gene EIF4A1 and fragile X-associated tremor/ataxia syndrome.