Interestingly, the depletion of eIF4B and eIF4H, co-factors which stimulate the activity of eIF4A, suppresses the neurodegenerative-associated rough eye phenotype of Drosophila models of FXTAS (Linsalata et al., 2019) and C9ORF72-ALS/FTD (Goodman et al., 2019), while the down-regulation of eIF4A either show no rescue effect or is lethal depending on the level of depletion. Here, EIF4A2 is linked to amyotrophic lateral sclerosis.