Interestingly, three known regulators of Synj1 activity, Dyrk1A, RCAN1 and intersectin (Cousin and Robinson, 2001; Koh et al., 2004; Adayev et al., 2006), map to chromosome 21, making the role of Synj1 in the pathogenesis of DS more intriguing. This evidence concerns the gene DYRK1A and Dravet syndrome.