For example, ZNF677 has been reported to be associated with the occurrence of non-small-cell lung cancer (Heller et al., 2015) and thyroid cancer (Siraj et al., 2021); ARHGAP40 may affect the development of laryngeal squamous cell carcinoma (Wang et al., 2021); the splicing event of the PUS3 gene at 11q24.2 has also been reported to be involved in a variety of cancers (Ajiro et al., 2016). The gene discussed is ARHGAP40; the disease is cancer.