Therefore, deletion or partial functional deficiency of SkIV2L may cause uncontrolled or dysregulated production of RLR ligands or sensors resulting in increased autoinflammatory responses in the absence of viral infection or increased susceptibility to systemic autoimmune diseases (Fernando et al., 2007; McKay et al., 2009; Yoneyama et al., 2014). The gene discussed is SKIC2; the disease is viral infectious disease.