In UCEC and COAD, we found that KRT17 translation from G (glycine) to A (alanine) (Gly22Ala) at site 22 is the most common; the change at this point may be the main reason for the occurrence and development of malignant tumors caused by KRT17, but the specific molecular mechanism is still not clear and needs further study. This evidence concerns the gene KRT17 and cancer.