PTK2 and cancer: PTK2 is reported to take part in various singling pathways that promote cancer growth and metastasis through kinase-dependent control of cell motility (Mitra et al., 2005), invasion (Shibue et al., 2012), cell survival (Cance and Golubovskaya, 2008; Frisch et al., 2013), and transcriptional events promoting epithelial to mesenchymal transition (EMT) (Li et al., 2011).