For example, H. cordata enhances HIF-1A/FOXO3 signaling transduction, causing the up-regulation of MEF2A expression in HepG2 cells, inhibiting the expression of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-Xl), promoting cell apoptosis, and inhibiting the growth of liver cancer cells transplanted into nude mice (Kim et al., 2017). The gene discussed is BCL2; the disease is liver cancer.