A high level of FANCD2 expression upregulated the immune inhibitor expression of CTLA4, PDCD1, and LAG3 while downregulating immunostimulators, such as IL6R, TMEM173, TNFSF13, CD40LG, and HHLA2, which indicates that FANCD2 contributes to tumor immune escape by modulating the immunosuppressive microenvironment. This evidence concerns the gene HHLA2 and neoplasm.