In turn, AC124067.4-hsa-miR-92b-3p (hsa-miR-589-5p)-PHYHIPL both decrease the MSI and TMB in COAD, thus reducing the risk of genome instability and alterations (Ren et al., 2021), whereas USP30-AS1 promotes mitochondrial quality control in glioblastoma cells (Wang et al., 2021), the USP30-AS1/miR-299-3p/PTP4A1 pathway aggravates the malignant progression of cervical cancer (Wang et al., 2021), and SNHG26 promotes the metastasis, growth, and cisplatin resistance of tongue squamous cell carcinoma through the PGK1/Akt/mTOR signaling pathway (Jiang et al., 2022). The gene discussed is PHYHIPL; the disease is tongue squamous cell carcinoma.