Eight different AS-DEGs (FOXG1, FOXM1, GNRH1, HAMP, IGFBP2, IL10, MPEG1, and VASH1) were revealed as independent prognostic factors in ccRCC patients (Figure 1C; Supplementary Table S5) and the following formula was generated to calculate the risk score: risk score = (expression of FOXG1 × 0.06305) + (expression of FOXM1 × 0.23742) + (expression of GNRH1× 0.25733) + (expression of HAMP × 0.10576) + (expression of IGFBP2 × 0.18935) + (expression of IL10 × 0.21992) + [expression of MPEG1 × (−0.27295)] + [expression of VASH1 × (−0.33497)]. The gene discussed is GNRH1; the disease is nonpapillary renal cell carcinoma.