At the molecular level, DLBCL can be divided into four genetic subtypes with different outcomes, including MCD (based on the co-occurrence of MYD88L265P and CD79B mutations), BN2 (based on BCL6 fusions and NOTCH2 mutations), N1 (based on NOTCH1 mutations), and EZB (based on EZH2 mutations and BCL2 translocations). Here, NOTCH2 is linked to diffuse large B-cell lymphoma.