CFHR1 and primary central nervous system lymphoma: Among these genes, CFH (complement factor H) and its related family members, CFHR1–5, encoded soluble proteins which play crucial roles in immune responses (Jozsi and Zipfel, 2008; Abarrategui-Garrido et al., 2009; Bajic et al., 2015), suggesting the involvement of the immune system in PCNSL.