For example, executive dysfunction was associated with catechol-O-methyltransferase (COMT), methylenetetrahydrofolate reductase (MTHFR) and BDNF in TLE and pediatric epilepsy (219, 220), memory impairment was associated with apolipoprotein E (APOE) and BDNF in TLE (221, 222), impaired working memory was associated with COMT and MTHFR in pediatric epilepsy (220), decreased information processing was associated with RE1- silencing transcription factor (REST) (219), and anxiety and depression were associated with BDNF and COMT (223). This evidence concerns the gene COMT and depressive disorder.