MAPT and Alzheimer disease: A careful review of the quadruple protein pathology in MMC residents points to the olfactory bulb, the ENS, brainstem, and cortex as regions with significant neuropathology: 202/203 subjects age 25.36 ± 9.23 y., exhibited all AD hallmarks, with tau pre-tangles, neurofibrillary tangles (NFT) Stages I-II, amyloid phases 1–2 by the 2 nd decade.