YTHDC1 and esophageal squamous cell carcinoma: The transcription events in downstream activated by NSs is partially intermediated through the binding of YTH-domain-containing protein 1 (YTHDC1) onto MALAT1-Δm6A. Interestingly, artificially tethering YTHDC1 onto MALAT1-Δm6A ESCC cells leads to the restoring of migration ability (Wang et al., 2021b), indicating that post-transcriptional modification may affect the oncogenic activity of MALAT1 in EC.