A meta-analysis suggested that C. sinensis combined with ACEI/ARB in patients with III to IV stage of DKD was effective to alleviate proteinuria, inflammation, and dyslipidemia by comparing 24-h proteinuria, urinary albumin excretion rate, microalbuminuria, serum creatinine, blood urea nitrogen, C-reactive protein, serum triglycerides, total cholesterol (Luo et al., 2015). This evidence concerns the gene CRP and diabetic kidney disease.