Exposure to hyperglycemia, the expression of NOX4 in mouse proximal renal tubular cells is increased, using NOX1/4 inhibitors (GKT136901) or NOX4 siRNA could block the damage of hyperglycemia to kidney, and reduce the production of proteinuria (Sedeek et al., 2013). The gene discussed is NOX4; the disease is Hyperglycemia.