NLRP3 and diabetic kidney disease: It could down-regulate the expression of P2X7R, and NLRP3 inflammasome (including NLRP3, ASC, caspase-1) in vivo and in vitro experiments, and the expression of downstream factors IL-1β and IL-18 was also significantly decreased, C. sinensis exerted an anti-inflammatory effect by antagonizing the P2X7R/NLRP3 inflammasome axis to relieve podocytes damage in DKD (Wang et al., 2018).