In recent years, it has been demonstrated that the activation of purinergic 2X7 receptor (P2X7R) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in podocytes are associated with the pathogenesis of DKD (Vonend et al., 2004; Shahzad et al., 2015). Here, NLRP3 is linked to diabetic kidney disease.