YFSJ remarkably reduced Atg16 (Figures 6B,K), Atg7 (Figures 6B,J) and LC3-2/LC3-1 ratio (Figures 6C,N), significantly increasing the expression of P62 (Figures 6B,L), suggesting that YFSJ remarkably inhibited tumor autophagic activities and subsequently blocked autophagy flow, which was shown by the accumulation of P62. Here, SQSTM1 is linked to neoplasm.