The inquiry of hub genes was also performed in TCGA via TIMER and the correlation between the genes of CCL2 (Figures 8A,B), MAPK1 (Figure 8C), IL1B (Figures 8D,E), ESR1 (Figure 8F), HIF1A (Figure 8G), IL1A (Figure 8H), and different immune cells (e.g., neutrophil, dendritic cell, and macrophage that belong to innate immune) infiltrated in lung adenocarcinoma (LUAD) and/or lung squamous cell carcinoma (LUSC) was positively significant. This evidence concerns the gene ESR1 and lung adenocarcinoma.