The survival map of 15 hub genes in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) from TCGA was investigated in GEPIA2, and as Supplementary Figure S2 showed that in LUSC, ESR1 and CCL2 are significantly positive in the hazard ratio (HR). The gene discussed is ESR1; the disease is lung adenocarcinoma.