GSDMD and myocardial infarction: Compared with the Sham group, the NLRP3, Caspase1, and GSDMD levels were significantly higher in the MI/RI group (0.24 ± 0.03 vs 0.72 ± 0.09, 0.25 ± 0.03 vs 0.88 ± 0.06, and 0.22 ± 0.06 vs 0.80 ± 0.07, respectively, p < 0.001; Figure 7B).