We discovered that the expression of hub genes in the yellow module was increased except for Ribosomal protein L17 (RPL17) and Heterogeneous nuclear ribonucleoprotein K (HNRNPK) in the GSE143303 (Supplementary Table S9), which indicated those hub genes other than RPL17 and HNRNPK play a role in severe asthma and do not particularly regulate severe eosinophilic asthma. Here, HNRNPK is linked to asthma.