NR3C1 and asthma: Lützner et al. (2012) found that FOXO3 is a glucocorticoid receptor target that has two functional glucocorticoid responsive regions in its promoter. In the presence of glucocorticoids, FOXO3 stimulates its expression via a positive autoregulatory feedback loop. Yuan et al. (2020) showed that FOXO3 increased in mild asthma patients and decreased in severe patients.