Fu et al. (2021) showed that SRSF1 expression was elevated in LPS-induced acute lung injury. However, it is unknown the role of SRSF1 that played in the development and progression of severe eosinophilic asthma. Only a few studies available so far showed that SRSF1 might be a potential biomarker for asthma (Maghsoudloo et al., 2020). This evidence concerns the gene SRSF1 and asthma.