PRELP and Scheie syndrome: ECM proteins, such as biglycan, fibromodulin, PRELP, type I collagen, lactotransferrin, and SERPINF1 were significantly reduced in the mouse model of MPS I, and further analysis identified several dysregulated mRNAs (e.g., Adamts12, Aspn, Chad, Col2a1, Col9a1, Hapln4, Lum, Matn1, Mmp3, Ogn, Omd, P4ha2, Prelp, and Rab32) (Heppner et al., 2015; Fecarotta et al., 2020).