However, a study by Oshrat and his team on colitis-associated colon cancer (CAC) convinced that HSF1 regulates extracellular matrix (ECM) remodeling in mouse colon fibroblasts to promote tumor progression by upregulating the transcription of genes encoding matrix proteins (FN1 and LAMA1), matrix remodeling enzymes (MMP7 and MMP9), and HSP47 (Levi-Galibov et al., 2020). The gene discussed is HSF1; the disease is colitis.