AKT1 and colorectal carcinoma: Western blotting results showed that IATL significantly lowered the protein levels of phospho-AKT (Ser473), phospho-mTOR (Ser2448) and phospho-70S6K (Thr421/Ser424) (a downstream molecule of mTORC1) in CRC cells, when compared with control cells (Figure 6A).